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Synthesis of β ‐Cyclodextrin‐[60]fullerene Conjugate and Its DNA Cleavage Performance
Author(s) -
Wang Jingjing,
Zhang Zhaoheng,
Wu Wei,
Jiang Xiqun
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300737
Subject(s) - chemistry , cyclodextrin , cleavage (geology) , cytotoxicity , conjugate , fullerene , photodynamic therapy , reactive oxygen species , dna , photochemistry , oxygen , irradiation , combinatorial chemistry , biochemistry , organic chemistry , in vitro , mathematical analysis , physics , geotechnical engineering , mathematics , fracture (geology) , nuclear physics , engineering
A water soluble β ‐cyclodextrin ( β ‐CD) functionalized [60]fullerene (C 60 ‐CD) was synthesized. The C 60 ‐CD‐induced generation of reactive oxygen species (ROS), and DNA‐cleavage ability and cytotoxicity of C 60 ‐CD were studied upon visible light irradiation, demonstrating that the compound is very promising in the applications of photodynamic therapy. The histological analyses demonstrate that C 60 ‐CD has no acute or subacute toxicity to living body.