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A Photo‐responsive Catalytic Vesicle with GPx Activity
Author(s) -
Xiao Ruiqing,
Zhou Lipeng,
Dong Zeyuan,
Gao Yuzhou,
Liu Junqiu
Publication year - 2014
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300695
Subject(s) - chemistry , glutathione peroxidase , cumene hydroperoxide , selenium , vesicle , antioxidant , catalysis , biochemistry , organic chemistry , membrane , catalase
Abstract Glutathione peroxidase (GPx) is a vital antioxidant enzyme involved in the reduction of reactive oxygen species and protects cells from oxidative damage. Consequently enormous efforts have been devoted to developing artificial catalysts with GPx function. Besides the research on enhancing the catalytic activity of GPx mimics, the design and construction of smart GPx models has also inspired great interest. Herein, a novel photo‐responsive selenium‐containing vesicular GPx model was successfully constructed by supramolecular self‐assembly of the cationic surfactant PyC 10 AzoC 10 Py with benzeneseleninic acid (PhSeO 2 H) through hydrophobic and electrostatic interactions in aqueous media. This selenium‐containing vesicular catalyst showed remarkable GPx‐like activity, which is 692 times more effective than PhSeO 2 H for the reduction of cumene hydroperoxide (CUOOH) by 4‐nitrobenzenethiol (NBT). Interestingly, when an equimolar amount of α ‐CD was added, the GPx‐like activity of the catalytic vesicle declines remarkably due to the vesicle disaggregation in the presence of α ‐CD. Whereas the biomimetic system was irradiated by UV light at 365 nm, the catalytic vesicle was formed again and the GPx‐like activity recovered.