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Palladium‐Catalyzed Desulfitative Cross‐Coupling of Sodium Arylsulfinates with Aryl Bromides and Chlorides: An Alternative Convenient Synthesis of Biaryls
Author(s) -
Zhou Chao,
Li Yaming,
Lu Yang,
Zhang Rong,
Jin Kun,
Fu Xinmei,
Duan Chunying
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300627
Subject(s) - chemistry , aryl , catalysis , palladium , base (topology) , trifluoromethyl , sodium , coupling reaction , organic chemistry , reaction conditions , combinatorial chemistry , mathematical analysis , alkyl , mathematics
An alternative method for synthesis of biaryls has been developed through the Pd catalyzed desulfitative coupling reaction of sodium arylsulfinates with aryl bromides and chlorides. The procedure tolerates a variety of functional groups, such as cyano, formyl, acetyl, chloro, methoxy, trifluoromethyl and heteroaromatic unit. The desired products were obtained in moderate to excellent yields under relatively mild reaction conditions without additives, base or co‐catalyst.