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Cu(I)‐Catalyzed Synthesis of 2‐Substituted Benzimidazoles from 2‐Iodoanilines and Amides
Author(s) -
Yuan Hua,
Chen Yongxin,
Song Jinli,
Chen Chunxia,
Chen Baohua
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300429
Subject(s) - chemistry , catalysis , acetic acid , reaction conditions , organic chemistry , combinatorial chemistry
A novel and efficient approach to the synthesis of 2‐substituted benzimidazoles has been developed via CuI/DMEDA‐catalyzed coupling reaction and post‐cyclization with glacial acetic acid from readily available 2‐iodoanilines and amides. This method is suitable for the construction of a variety of benzimidazoles in moderate to good yields under short reaction times.
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