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Copper(I)‐Catalyzed Trifluoromethylation of Phthalic Anhydride Derivatives with (Trifluoromethyl)trimethylsilane
Author(s) -
Wu Mingxi,
Wang Mingjin,
Cao Song
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300357
Subject(s) - trifluoromethylation , chemistry , phthalic anhydride , trimethylsilane , trifluoromethyl , reagent , nucleophile , catalysis , copper , organic chemistry , alkyl
An efficient copper‐catalyzed trifluoromethylation of substituted phthalic anhydrides using (trifluoromethyl) trimethylsilane (Me 3 SiCF 3 ) as a nucleophilic trifluoromethylating reagent in the presence of 1,10‐phenanthroline and KF, followed by quenching the reaction mixture with water has been developed. A possible mechanism was suggested.