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Nickel‐Catalyzed ortho ‐Selective Hydrodefluorination of N ‐Containing Heterocycle‐Polyfluoroarenes
Author(s) -
He Yi,
Chen Zhao,
He ChunYang,
Zhang Xingang
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300327
Subject(s) - chemistry , catalysis , triethylsilane , nickel , combinatorial chemistry , chelation , organic chemistry
An effective and facile method for preparation of partially fluorinated aromatics via Nickel catalyzed, chelation‐assisted ortho selective hydrodefluorination of polyfluoroarnes with triethylsilane has been developed, in which N ‐containing heterocycles were used as directing groups. The advantage of this protocol is its simple catalytic system with use of inexpensive and readily available NiCl 2 ·6H 2 O as a catalyst.
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