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Application of Functionalized N , S ‐Ketene Acetals–Microwave‐Assisted Three‐Component Domino Reaction for Rapid Direct Access to Imidazo[1,2‐ a ]pyridines
Author(s) -
Li Ming,
Li Tengfei,
Zhao Kelong,
Wang Mingda,
Wen Lirong
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300252
Subject(s) - chemistry , malononitrile , dabco , ketene , domino , cascade reaction , catalysis , regioselectivity , microwave irradiation , component (thermodynamics) , tandem , combinatorial chemistry , microwave , reaction conditions , organic chemistry , physics , materials science , quantum mechanics , composite material , thermodynamics
Abstract Imidazo[1,2‐ a ]pyridines have been successfully synthesized in moderate to good yields via a tandem three‐component reaction of ethyl 2‐(3‐oxo‐3‐arylpropanethioamido)acetates with aromatic aldehydes and malononitrile by means of microwave irradiation using DABCO as the catalyst. The advantages of this method including high chemo‐ and regioselectivity make this new strategy highly attractive.