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A Highly Diastereoselective Three‐component Domino Reaction in Water Yielding Poly‐substituted 4,5‐Dihydropyrroles
Author(s) -
Tong Guangjing,
Xu Haiwei,
Fan Wei,
Jiang Bo,
Wang Shuliang,
Tu Shujiang
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300249
Subject(s) - chemistry , domino , hydroxylation , component (thermodynamics) , pyrrole , cascade reaction , combinatorial chemistry , reaction conditions , organic chemistry , polymer chemistry , catalysis , physics , thermodynamics , enzyme
An efficient methodology for highly diastereoselective synthesis of poly‐substituted 4,5‐dihydropyrrole derivatives from readily available common reactants in water has been developed. During domino processes, the formation of pyrrole skeleton and its C2‐hydroxylation and C3‐arylamination were readily achieved via metal‐free [3+2] heterocyclization in a one‐pot operation.