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Enantioselective Organocatalytic Aza‐Michael Additions of Phthalimide Derivatives to α , β ‐Unsaturated Aldehydes
Author(s) -
Ma Shijun,
Liu Ming,
Huang Yaodong,
Wang Yongmei
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300175
Subject(s) - chemistry , phthalimide , enantioselective synthesis , michael reaction , organic chemistry , adduct , nucleophile , addition reaction , organocatalysis , nitrogen , catalysis , medicinal chemistry
Phthalimide derivatives as nitrogen nucleophiles with α , β ‐unsaturated aldehydes for asymmetric aza‐Michael additions have been reported. The reactions proceed smoothly to afford corresponding Michael adducts in good yields (up to 98%) and enantioselectivities (up to 95% ee ).
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