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Easy One‐Pot Synthesis of 1‐Monosubstituted Aliphatic 1,2,3‐Triazoles from Aliphatic Halides, Sodium Azide and Propiolic Acid by a Click Cycloaddition/Decarboxylation Process
Author(s) -
Zhang Zhongkui,
Kuang Chunxiang
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300155
Subject(s) - chemistry , sodium azide , decarboxylation , cycloaddition , halide , azide , click chemistry , organic chemistry , sodium , medicinal chemistry , catalysis
1‐Monosubstituted aliphatic 1,2,3‐triazoles were synthesized by a one‐pot reaction from aliphatic halides (Cl and Br), sodium azide and propiolic acid. The yields ranged from moderate to good. The reaction was easily carried out in DMF with Cs 2 CO 3 at 100°C by copper‐catalyzed click cycloaddition/decarboxylation.
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