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Efficient Synthesis of Unsymmetrical Heteroaryl Ethers by a Transition Metal‐Free CO Cross‐Coupling Reaction of Activated and Unactivated Heteroaryl Chlorides with Alcohols and Phenols
Author(s) -
Liu Quan,
Lu Zhongxiang,
Ren Wenfei,
Shen Kaibo,
Wang Yu,
Xu Qing
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300120
Subject(s) - chemistry , phenols , aryl , transition metal , alkyl , coupling reaction , primary (astronomy) , organic chemistry , reaction conditions , combinatorial chemistry , catalysis , physics , astronomy
By optimizing the reaction conditions via a careful screening of the bases and solvents, we developed an efficient transition metal‐free method for CO cross‐coupling of activated and unactivated heteroaryl chlorides with primary and secondary alcohols and phenols, providing a simple, efficient, and practical method for synthesis of the useful unsymmetrical heteroaryl alkyl and heteroaryl aryl ethers.