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Diastereoselective Synthesis of Arylidene Bis(3‐arylaminoacrylates) via One‐pot Domino Reactions
Author(s) -
Liu Zhenming,
Zhang Lili,
Sun Jing,
Yan Chaoguo
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300094
Subject(s) - chemistry , domino , cascade reaction , reaction conditions , medicinal chemistry , catalysis , primary (astronomy) , organic chemistry , physics , astronomy
The functionalized arylidene bis(3‐arylaminoacrylates) were efficiently prepared by FeCl 3 catalyzed one‐pot domino reactions of primary amines, methyl propiolate and aromatic aldehydes. When isatins were utilized under similar conditions, only 2‐oxoindolinyl 3‐arylaminoacrylates were obtained in moderate yields. 1 H NMR data and single crystal structures indicated that this reaction has high diastereoselectivity.