Diastereoselective Synthesis of Arylidene Bis(3‐arylaminoacrylates)  via  One‐pot Domino Reactions | Zendy

Liu Zhenming | Zendy; Zhang Lili | Zendy; Sun Jing | Zendy; Yan Chaoguo | Zendy

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Diastereoselective Synthesis of Arylidene Bis(3‐arylaminoacrylates) via One‐pot Domino Reactions

Author(s) -

Liu Zhenming,

Zhang Lili,

Sun Jing,

Yan Chaoguo

Publication year - 2013

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201300094

Subject(s) - chemistry , domino , cascade reaction , reaction conditions , medicinal chemistry , catalysis , primary (astronomy) , organic chemistry , physics , astronomy

The functionalized arylidene bis(3‐arylaminoacrylates) were efficiently prepared by FeCl 3 catalyzed one‐pot domino reactions of primary amines, methyl propiolate and aromatic aldehydes. When isatins were utilized under similar conditions, only 2‐oxoindolinyl 3‐arylaminoacrylates were obtained in moderate yields. 1 H NMR data and single crystal structures indicated that this reaction has high diastereoselectivity.

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