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Copper Hydride‐Catalyzed Conjugate Reduction‐Aldol Addition Domino Reaction of α , β ‐Unsaturated Carboxylates with Ketones
Author(s) -
Li Zengchang,
Jiang Lan,
Li Zhengning,
Chen Huiying
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300036
Subject(s) - chemistry , hydride , conjugate , aldol reaction , catalysis , silane , reagent , hydrosilylation , addition reaction , medicinal chemistry , copper , organic chemistry , combinatorial chemistry , polymer chemistry , metal , mathematical analysis , mathematics
Copper hydride‐catalyzed conjugate reduction‐intermolecular aldol addition domino reactions were realized using α , β ‐unsaturated carboxylates as hydride acceptors and a silane as the reducing reagent. High diastereoselectivities were achieved with 4,5‐bis(diphenylphosphino)‐9,9‐dimethylxanthene as the ligand and tert ‐butyl acrylate as the hydride acceptor.