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Efficient Total Synthesis of ( S )‐Dihydroresorcylide, a Bioactive Twelve‐Membered Macrolide
Author(s) -
Zhang Li,
Ma Wenquan,
Xu Lili,
Deng Fei,
Guo Yuewei
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201300016
Subject(s) - chemistry , orcinol , total synthesis , ring closing metathesis , carbonylation , stereochemistry , metathesis , salt metathesis reaction , ring (chemistry) , sequence (biology) , combinatorial chemistry , ether , macrolide antibiotics , organic chemistry , antibiotics , catalysis , biochemistry , carbon monoxide , polymerization , polymer , erythromycin
The efficient synthesis of ( S )‐dihydroresorcylide ( 1a ) along with trans ‐resorcylide dimethyl ether ( 2b ), was achieved in linear 9 steps from commercially available orcinol monohydrate ( 6 ) with esterification, carbonylation, and ring‐closing metathesis (RCM) as the key steps in the synthetic sequence.