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Cover Picture: Inhibitors of HIV‐1 Integrase‐Human LEDGF/p75 Interaction Identified from Natural Products via Virtual Screening (Chin. J. Chem. 12/2012)
Author(s) -
Hu Guoping,
Li Xi,
Li Yaozong,
Sun Xianqiang,
Liu Guixia,
Li Weihua,
Huang Jin,
Shen Xu,
Tang Yun
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201290035
Subject(s) - integrase , chemistry , virtual screening , integrase inhibitor , human immunodeficiency virus (hiv) , natural product , drug discovery , computational biology , cover (algebra) , combinatorial chemistry , stereochemistry , virology , antiretroviral therapy , biochemistry , dna , viral load , mechanical engineering , engineering , biology
The cover picture shows the discovery of inhibitors targeting HIV‐1 integrase‐human LEDGF/p75 interaction via virtual screening. One of the most challenges for anti‐HIV therapy is the rapid emergence of drug resistance. Protein‐protein interaction inhibitors bring us hopes to overcome the viral resistance. We conducted a virtual screening combined with bioassays to search such inhibitors from natural product library. Several compounds were discovered to block integrase‐ LEDGF/p75 interaction with potent activities. These findings could be helpful for anti‐HIV drug discovery. More details are discussed in the article by Tang et al . on page 2752–2758.