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Cover Picture: The First Catalytic Asymmetric Morita‐Baylis‐Hillman Reaction of Acrolein with Aromatic Aldehydes (Chin. J. Chem. 11/2012)
Author(s) -
Zeng Xingping,
Liu Yunlin,
Ji Congbin,
Zhou Jian
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201290029
Subject(s) - acrolein , chemistry , aldehyde , adduct , catalysis , baylis–hillman reaction , nucleophile , organic chemistry , medicinal chemistry
The cover picture shows the first catalytic asymmetric Morita‐Baylis‐Hillman (MBH) reaction of acrolein with aromatic aldehydes. Simplicity is beauty. As one of the simplest nucleophiles in MBH reaction, acrolein has never been used for the catalytic asymmetric reaction with aldehydes, although the resulting MBH adducts, with a versatile aldehyde group, are extremely useful. The Hatakeyama's catalyst β ‐isocupreidine, in combination with 20 mol% of 2,6‐dimethoxybenzoic acid, is found to be able to catalyze the reaction of acrolein with aromatic aldehydes to give the desired MBH adducts in up to 81% ee . More details are discussed in the article by Zhou et al . on page 2631–2635.