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Copper‐Catalyzed Amination of Aryl Halides with Aqueous Ammonia under Mild Conditions
Author(s) -
Quan Zhengjun,
Xia Haidong,
Zhang Zhang,
Da Yuxia,
Wang Xicun
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201201240
Subject(s) - chemistry , amination , halide , aqueous solution , ammonia , catalysis , aryl , copper , homogeneous , sodium ascorbate , coupling reaction , organic chemistry , inorganic chemistry , ascorbic acid , alkyl , physics , food science , thermodynamics
Abstract A Cu(I) generated in situ from CuSO 4 ·5H 2 O/sodium ascorbate catalyzed cross‐coupling reaction of aryl halides with aqueous ammonia for the synthesis of primary aromatic amines has been developed. Key to the success included the application of aqueous ammonia under a homogeneous condition.