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Synthesis and Cytotoxic Evaluation of Novel Platinum(II) Complexes with C 2 ‐Asymmetric and C 2 ‐Symmetric Chiral Vicinal Diamines
Author(s) -
Zhang Chen,
Liu Hongrui,
Yang Qing,
Chang Jun,
Sun Xun
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201201168
Subject(s) - chemistry , platinum , cytotoxicity , oxaliplatin , stereochemistry , cancer cell lines , k562 cells , vicinal , cell culture , cancer cell , cell , cancer , organic chemistry , biochemistry , in vitro , medicine , colorectal cancer , catalysis , genetics , biology
A series of new platinum(II) complexes with C 2 ‐asymmetric and C 2 ‐symmetric 1,2‐diamines were designed and synthesized by convenient methods, involving samarium diiodide induced reductive coupling as the key step. The results of cytotoxicity showed that compounds ( R , R )‐ 11a and ( S , S )‐ 11a , two novel platinum(II) complexes with asymmetric 1,2‐diamines, exhibited more potent cytotoxicity than that of oxaliplatin against all leukemia cell lines. Interestingly, ( R , R )‐ 11a and ( S , S )‐ 11a demonstrated less potent activity against three solid cancer cell lines than that of oxaliplatin, which indicated that these two compounds may only selectively inhibit the leukemia cell lines. In contrast, ( R , R )‐ 15a and ( S , S )‐ 15a , two platinum(II) complexes with symmetric 1,2‐diamines, showed similar cytotoxicity to that of oxaliplatin against all leukemia cell lines and more potent activity against solid cancer cell lines. Further flow cytometry data indicated that ( R , R )‐ 11a could obviously arrest leukemia K562 cells in G2/M phases.