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Gold‐Catalyzed Direct Indolation of Tetrahydroisoquinolines
Author(s) -
Zhang Yan,
Luo Sha,
Feng Bainian,
Zhu Chengjian
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201201154
Subject(s) - chemistry , catalysis , indole test , aryl , alkylation , combinatorial chemistry , coupling reaction , reaction conditions , organic chemistry , alkyl
Nitrogen‐containing heterocyclic compounds are important motifs of pharmaceuticals and functional materials, and there has been a growing interest in new synthetic methods for their preparations. In this paper, we report a direct cross‐coupling reaction of indole with N ‐aryl tetrahydroisoquinolines in the presence of gold catalyst. The reaction is compatible with a wide range of substituted indoles, to enable the formation of various alkylated heteroarenes under very mild reaction conditions.