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Stereospecific Synthesis of Drospirenone
Author(s) -
Deng Gang,
Huang Zuogang,
Zhao Xiaolong,
Li Zheng,
Li Yuanchao,
Jiang Biao
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201201147
Subject(s) - stereospecificity , chemistry , cyclopropanation , alcohol , tandem , reduction (mathematics) , sesquiterpene , stereochemistry , organic chemistry , catalysis , materials science , geometry , mathematics , composite material
A procedure for the stereospecific synthesis of drospirenone has been developed. The key steps included the stereospecific reduction of the C 7 ‐tertiary alcohol with ZnI 2 /Et 3 SiH, a novel mild and stereospecific tertiary alcohol reduction system, and the tandem oxidation/cyclopropanation reactions.
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