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An Efficient Semi‐Synthetic Method to Construct Docetaxel via Sterically Crowded Linear Side Chain Esterification
Author(s) -
Shen Xin,
Yang Jidong,
Zhan Huaxing,
Wang Hu,
Wu Shaohong,
Chen Zili
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201201142
Subject(s) - chemistry , docetaxel , racemization , steric effects , derivative (finance) , construct (python library) , side chain , nitrogen atom , combinatorial chemistry , stereochemistry , position (finance) , chain (unit) , organic chemistry , group (periodic table) , physics , finance , astronomy , medicine , surgery , chemotherapy , computer science , financial economics , economics , programming language , polymer
An efficient semi‐synthetic method was developed to construct docetaxel 1 by using N , N ‐di‐Boc protected linear isoserine derivative 5 as the side chain source, in which, bulky protecting group on the nitrogen atom blocked C‐2′ position and prohibited unavoidable racemization in previous studies.