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Ethylenediamine: A Highly Effective Catalyst for One‐Pot Synthesis of Aryl Nitroalkenes via Henry Reaction and Dehydration
Author(s) -
Yang Jianxin,
Dong Jing,
Lü Xia,
Zhang Qiang,
Ding Wei,
Shi Xiaoxin
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201201094
Subject(s) - nitromethane , nitroethane , chemistry , ethylenediamine , catalysis , aryl , nitroaldol reaction , organic chemistry , medicinal chemistry , enantioselective synthesis , alkyl
Ethylenediamine (H 2 NCH 2 CH 2 NH 2 ) was found to be a highly effective catalyst for the condensation of aryl aldehydes with nitromethane (or nitroethane). When 1%–2% (mol%) of ethylenediamine was used as the catalyst, the one‐pot reaction of aryl aldehydes with nitromethane (or nitroethane) by refluxing for 3–10 h efficiently afforded various arylnitroalkenes 1a – 1y in 85%–97% yields.

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