A Concise Total Synthesis of Amphidinin B

A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19‐membered cycloalkene intermediates designed for diverted total synthesis of amphidinolide T1 and T3–T5. The 1 H and 13 C NMR spectra of the synthesized amphidinin B in C 6 D 6 and CDCl 3 were compared with those for the natural and synthetic forms reported in the literature, showing solvent‐dependence of the 1 H and 13 C NMR signals of amphidinin B in C 6 D 6 and CDCl 3 .