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A Concise Total Synthesis of Amphidinin B
Author(s) -
Wu Dongdong,
Wu Jinlong,
Dai Weimin
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201201069
Subject(s) - chemistry , cycloalkene , total synthesis , stereochemistry , organic chemistry , hydrocarbon
A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19‐membered cycloalkene intermediates designed for diverted total synthesis of amphidinolide T1 and T3–T5. The 1 H and 13 C NMR spectra of the synthesized amphidinin B in C 6 D 6 and CDCl 3 were compared with those for the natural and synthetic forms reported in the literature, showing solvent‐dependence of the 1 H and 13 C NMR signals of amphidinin B in C 6 D 6 and CDCl 3 .