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Formation of Chiral α ‐Monofluorinated‐ β ‐amino Esters through Organocatalytic Asymmetric Reduction of α ‐Fluoro‐ β ‐enamino Esters by Trichlorosilane
Author(s) -
Zhang Peng,
Wang Chao,
Zhou Li,
Sun Jian
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201201067
Subject(s) - chemistry , trichlorosilane , hydrosilylation , catalysis , enantioselective synthesis , reduction (mathematics) , urea , organic chemistry , medicinal chemistry , geometry , mathematics , silicon
A concise method was developed to prepare chiral α ‐monofluorinated‐ β ‐amino esters through N ‐sulfinyl urea catalyzed asymmetric hydrosilylation of α ‐fluoro‐ β ‐enamino esters, which affords high yields, good to high diastereoselectivities (up to>99/1), and moderate to good enantioselectivities (up to 83% ee ).
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