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Expedient Synthesis of ( R )‐Curcuphenol: A Chiral Pool Strategy
Author(s) -
Feng Jing,
Zhu Guili,
Liu Bo,
Zhou Xiangdong
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201201024
Subject(s) - chemistry , total synthesis , citronellal , enantioselective synthesis , combinatorial chemistry , scalability , stereochemistry , nanotechnology , organic chemistry , catalysis , database , computer science , materials science
Curcuphenol is an interesting sesquiterpenoid with diverse bioactivities. Exploration of a concise and scalable synthetic route is still of significance in spite that many asymmetric total syntheses have been achieved. We report an expedient asymmetric synthesis of ( R )‐curcuphenol from citronellal, which features only two purification operations in the overall six‐step synthesis.