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Decarboxylative Alkylation of β ‐Keto Acids with Isochromans under Oxidative Conditions
Author(s) -
Chen Yan,
Tian ShiKai
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200994
Subject(s) - chemistry , alkylation , regioselectivity , oxidative phosphorylation , hexafluorophosphate , organic chemistry , catalysis , biochemistry , ionic liquid
An unprecedented decarboxylative alkylation reaction of β ‐keto acids with isochromans has been developed under oxidative conditions. A range of β ‐keto acids smoothly undergo decarboxylative alkylation with isochromans in the presence of 2,2,6,6‐tetramethylpiperdine‐1‐oxoammonium hexafluorophosphate to give structurally diverse 1‐acylmethylisochromans in moderate to excellent yields with extremely high regioselectivity.