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Synthesis and Evaluation of the Analogues of Penicillide against Cholesterol Ester Transfer Protein
Author(s) -
Zhang Qiao,
Deng Chunlin,
Fang Lisong,
Xu Wenwei,
Zhao Qun,
Zhang Jiange,
Wang Yiping,
Lei Xinsheng
Publication year - 2013
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200977
Subject(s) - chemistry , cholesterylester transfer protein , in vitro , stereochemistry , cholesterol , combinatorial chemistry , biochemistry , lipoprotein
A series of penicillide analogues, with modifications at C‐3 and C‐9 positions, are synthesized as potential cholesteryl ester transfer protein (CETP) inhibitors. The preliminary in vitro inhibition assay provided some valuable structure‐activity relationship information about penicillide.