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Ir‐Catalyzed Enantioselective Hydrogenation of 2 H ‐1,4‐Benzoxazines with a Chiral 1,2,3,4‐Tetrahydro‐1‐naphthylamine Derived Phosphine‐aminophosphine Ligand
Author(s) -
Hu Juan,
Wang Daoyong,
Zheng Zhuo,
Hu Xiangping
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200944
Subject(s) - chemistry , phosphine , ligand (biochemistry) , catalysis , enantioselective synthesis , asymmetric hydrogenation , aryl , naphthylamine , combinatorial chemistry , medicinal chemistry , organic chemistry , receptor , biochemistry , alkyl
Unsymmetrical hybrid chiral phosphine‐aminophosphine ligand derived from 1,2,3,4‐tetrahydro‐1‐naphthylamine has been found to be highly efficient in the Ir‐catalyzed asymmetric hydrogenation of various 3‐aryl‐2 H ‐1,4‐benzoxazines, providing good enantioselectivities (up to 95% ee ) and high catalytic activity (S/C up to 5000).
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