Premium
Sugar‐fiber Imprinting to Generate Microgrooves on Polymeric Film Surfaces for Contact Guidance of Cells
Author(s) -
Qu Zehua,
Ding Jiandong
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200841
Subject(s) - chemistry , polymer , plga , biocompatible material , imprinting (psychology) , sugar , nanotechnology , anisotropy , surface modification , chemical engineering , biomedical engineering , organic chemistry , materials science , biochemistry , optics , medicine , physics , in vitro , gene , engineering
Anisotropic surface topography is known to induce the contact guidance of cells, and facile and biocompatible approaches of the physical modification of the pertinent matrix surfaces are thus meaningful for biomaterials. Herein, we put forward a sugar‐fiber imprinting technique to generate microgrooves on hydrophobic polymers demonstrated by the poly(lactic‐ co ‐glycolic acid) (PLGA) films. Microgrooves were conveniently generated after removing sugar fibers simply by water. The resulting locally anisotropic microgrooves were confirmed to elongate the cells cultured on the surface.