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Enantioselective and α ‐Regioselective Allylic Amination of Morita‐Baylis‐Hillman Acetates with Simple Aromatic Amines Catalyzed by Planarly Chiral Ligand/Palladium Catalyst
Author(s) -
Wang Yan,
Zhang Tao,
Liu Li
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200771
Subject(s) - chemistry , regioselectivity , amination , enantioselective synthesis , allylic rearrangement , catalysis , ligand (biochemistry) , palladium , organic chemistry , combinatorial chemistry , receptor , biochemistry
An asymmetric allylic amination of Morita‐Baylis‐Hillman acetates with simple aromatic amines catalyzed by planarly chiral ligand/palladium‐catalyst was developed in good yield with excellent α ‐regioselectivity ( α / γ up to 30:1) and moderate enantioselectivity (up to 70% ee ).