Enantioselective Morita‐Baylis‐Hillman Reaction Organocatalyzed by Glucose‐based Phosphinothiourea | Zendy

Yang Weihong | Zendy; Sha Feng | Zendy; Zhang Xin | Zendy; Yuan Kui | Zendy; Wu Xinyan | Zendy

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Enantioselective Morita‐Baylis‐Hillman Reaction Organocatalyzed by Glucose‐based Phosphinothiourea

Author(s) -

Yang Weihong,

Sha Feng,

Zhang Xin,

Yuan Kui,

Wu Xinyan

Publication year - 2012

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201200740

Subject(s) - chemistry , enantioselective synthesis , baylis–hillman reaction , allylic rearrangement , bifunctional , yield (engineering) , organic chemistry , catalysis , organocatalysis , materials science , metallurgy

A class of bifunctional phosphinothioureas derived from saccharide was developed as new organocatalysts for the enantioselective Morita‐Baylis‐Hillman reaction between acrylates and aldehydes. With 10 mol% of glucose‐based phosphinothiourea 1d , the allylic alcohols were obtained in up to 96% yield and 83% ee under mild reaction conditions.

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