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Asymmetric Aldol Reaction Catalyzed by Modularly Designed Organocatalysts
Author(s) -
Sinha Debarshi,
Mandal Tanmay,
Gogoi Sanjib,
Goldman Joshua J.,
Zhao John Conggui
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200639
Subject(s) - aldol reaction , chemistry , cinchona , organocatalysis , catalysis , aldehyde , enantioselective synthesis , cinchona alkaloids , organic chemistry , alkaloid , combinatorial chemistry
Abstract The self‐assembly of the precatalyst modules, which are amino acids and cinchona alkaloid derivatives, leads to the direct formation of the desired organocatalysts without any synthesis. These modularly designed organocatalysts (MDOs) may be used for catalyzed asymmetric aldol reaction. Depending on structure of the aldehyde substrates, the corresponding aldol products may be obtained in mediocre to excellent ee values (up to 92% ee ) with moderate diastereoselectivities (up to 79:21 dr ).