Cucurbit[ 7 ]uril‐Based Vesicles Formed by Self‐assembly of Supramolecular Amphiphiles | Zendy

Li Jiaxi | Zendy; Zhou Lipeng | Zendy; Luo Quan | Zendy; Wang Yongguo | Zendy; Zhang Chunqiu | Zendy; Lu Wei | Zendy; Xu Jiayun | Zendy; Liu Junqiu | Zendy

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Cucurbit[ 7 ]uril‐Based Vesicles Formed by Self‐assembly of Supramolecular Amphiphiles

Author(s) -

Li Jiaxi,

Zhou Lipeng,

Luo Quan,

Wang Yongguo,

Zhang Chunqiu,

Lu Wei,

Xu Jiayun,

Liu Junqiu

Publication year - 2012

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201200603

Subject(s) - cucurbituril , supramolecular chemistry , chemistry , amphiphile , vesicle , cavitand , self assembly , aqueous solution , amphiphilic molecule , supramolecular assembly , combinatorial chemistry , drug delivery , molecule , nanotechnology , organic chemistry , copolymer , membrane , biochemistry , materials science , polymer

Cucurbituril (CB), a well‐known macrocyclic cavitand, has been used extensively to construct supramolecular aggregates. Based on host‐guest intertactions, an adamantanyl derivative guest molecule was designed and synthesized to prepare a supramolecular amphiphile with cucurbit[7]uril. In aqueous solution, the cucurbit[7]uril based supramolecular amphiphiles self‐assemble into well‐defined vesicles, and their disassembly can be achieved by addition of excess competitive agent 1‐adamantanamine hydrochloride. This vesicle functions as a new nanocapsule to encapsulate molecules within its hollow cavity. Through competitive disassembly of supramolecular amphiphiles, the vesicles behave as a novel drug delivery carrier.

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