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Cucurbit[ 7 ]uril‐Based Vesicles Formed by Self‐assembly of Supramolecular Amphiphiles
Author(s) -
Li Jiaxi,
Zhou Lipeng,
Luo Quan,
Wang Yongguo,
Zhang Chunqiu,
Lu Wei,
Xu Jiayun,
Liu Junqiu
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200603
Subject(s) - cucurbituril , supramolecular chemistry , chemistry , amphiphile , vesicle , cavitand , self assembly , aqueous solution , amphiphilic molecule , supramolecular assembly , combinatorial chemistry , drug delivery , molecule , nanotechnology , organic chemistry , copolymer , membrane , biochemistry , materials science , polymer
Cucurbituril (CB), a well‐known macrocyclic cavitand, has been used extensively to construct supramolecular aggregates. Based on host‐guest intertactions, an adamantanyl derivative guest molecule was designed and synthesized to prepare a supramolecular amphiphile with cucurbit[7]uril. In aqueous solution, the cucurbit[7]uril based supramolecular amphiphiles self‐assemble into well‐defined vesicles, and their disassembly can be achieved by addition of excess competitive agent 1‐adamantanamine hydrochloride. This vesicle functions as a new nanocapsule to encapsulate molecules within its hollow cavity. Through competitive disassembly of supramolecular amphiphiles, the vesicles behave as a novel drug delivery carrier.