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A Convenient Hydrogenation Method for the Synthesis of Metallo‐mesoporphyrin IX Dimethyl Esters via Self‐catalyzed CoCl 2 ‐NaBH 4 Reagent System
Author(s) -
Xu Shichao,
Hu Bingcheng,
Hu Tianjing,
Wang Huan,
Huang Xiuyou,
Lou Xingkun,
Liu Zuliang
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200581
Subject(s) - chemistry , reagent , porphyrin , catalysis , protoporphyrin ix , combinatorial chemistry , protoporphyrin , reaction conditions , organic chemistry , photodynamic therapy
Abstract A convenient protocol has been developed for the hydrogenation of metallo‐protoporphyrin IX dimethyl esters (MPPDMEs) to their mesoporphyrin analogues using CoCl 2 ‐NaBH 4 reagent system. Metallo‐porphyrin complexes were found to perform as self‐catalysts in this procedure. This method provides several advantages such as safe and simple procedure, short reaction time, high yields and low cost.