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Catalytic, Conjugate Reduction‐Aldol Addition Reaction of β′ ‐Oxoalkyl α,β ‐Unsaturated Carboxylates
Author(s) -
Zheng Aijun,
Jiang Lan,
Li Zhengning
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200523
Subject(s) - chemistry , aldol reaction , conjugate , catalysis , silanes , phosphine , intramolecular force , copper , ligand (biochemistry) , medicinal chemistry , organic chemistry , silane , biochemistry , receptor , mathematical analysis , mathematics
Intramolecular conjugate reduction‐aldol addition reactions of β′ ‐oxoalkyl α , β ‐unsaturated carboxylates were performed in the presence of copper catalysts generated in situ from copper salts, phosphine ligands and silanes. Moderate to good yields and high diastereoselectivities were obtained in 15 min to 3 h using bis[(2‐diphenylphosphino)phenyl] ether as the ligand.