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Stereoselective Synthesis of Optically Active Hydrobenzoins via Asymmetric Hydrogenation of Benzils with Ru(OTf)(TsDPEN)(η 6 ‐cymene) as the Pre‐catalyst
Author(s) -
Huang Xiaofei,
Li Naikai,
Geng Zhicong,
Pan Fengfeng,
Wang Xingwang
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200393
Subject(s) - chemistry , optically active , catalysis , asymmetric hydrogenation , methanol , stereoselectivity , organic chemistry , combinatorial chemistry , medicinal chemistry , enantioselective synthesis
Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been developed for asymmetric hydrogenation of benzils with Ru(OTf)(TsDPEN)(η 6 ‐cymene) as a pre‐catalyst in methanol. Therefore, a series of chiral hydrobenzoins was synthesized in good yields with good to moderate diastereoselectivities and good to excellent enantioselectivities.