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Synthesis of Functionalized 2‐Aminopyrroles by Lewis Acid Catalyzed Ring‐opening of 1,1,2,3‐Tetrasubstituted Cyclopropanes with Arylamines
Author(s) -
Han Ying,
Fu Qin,
Tang Wanquan,
Yan Chaoguo
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200229
Subject(s) - chemistry , cyclopropane , lewis acids and bases , nucleophile , ring (chemistry) , catalysis , steric effects , medicinal chemistry , nucleophilic substitution , stereochemistry , organic chemistry
Under the catalysis of Lewis acid Co(ClO 4 ) 2 the reaction of the sterically hindered 1,1,2,3‐tetrasubstituted cyclopropanes with arylamines in refluxing THF gave the functionalized 2‐aminopyrroles with sequential ring‐opening of cyclopropane, nucleophilic substitution, nucleophilic addition of cyano group and recyclization processes.