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Direct Asymmetric Michael Additions of Ketones to Nitroolefins and Chalcones Catalyzed by a Chiral C 2 ‐Symmetric Pyrrolidine‐based Tetraamine
Author(s) -
Ma Shijun,
Wu Lulu,
Liu Ming,
Wang Yongmei
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200214
Subject(s) - pyrrolidine , chemistry , michael reaction , catalysis , organic chemistry , addition reaction , combinatorial chemistry
C 2 ‐Symmetric pyrrolidine‐based tetraamine, available from commercially starting materials, showed good catalytic activity for asymmetric Michael additions of ketones to nitroalkenes especially to chalcones. The reactions proceeded to give the corresponding products in good yields and in a highly selective manner.