Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells | Zendy

Zheng Shuyan | Zendy; Fu Runzhong | Zendy; Shen Zhengwu | Zendy

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Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells

Author(s) -

Zheng Shuyan,

Fu Runzhong,

Shen Zhengwu

Publication year - 2012

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201200146

Subject(s) - chemistry , k562 cells , jurkat cells , raji cell , cancer cell , apoptosis , leukemia , isoflavonoid , cancer research , stereochemistry , cancer , in vitro , biochemistry , immune system , t cell , flavonoid , immunology , medicine , biology , antioxidant

We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activity of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells.

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