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Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells
Author(s) -
Zheng Shuyan,
Fu Runzhong,
Shen Zhengwu
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200146
Subject(s) - chemistry , k562 cells , jurkat cells , raji cell , cancer cell , apoptosis , leukemia , isoflavonoid , cancer research , stereochemistry , cancer , in vitro , biochemistry , immune system , t cell , flavonoid , immunology , medicine , biology , antioxidant
We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activity of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells.