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Synthesis and Antifungal Activities of New Type β ‐Methoxyacrylate‐Based Strobilurin Analogues
Author(s) -
Zhang Xiang,
Liu Huijun,
Gao Yongxin,
Wang Huili,
Guo Baoyuan,
Li Jianzhong
Publication year - 2012
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201200101
Subject(s) - strobilurin , botrytis cinerea , chemistry , azoxystrobin , pharmacophore , fungicide , antifungal , phytophthora capsici , bioassay , stereochemistry , botany , microbiology and biotechnology , pepper , food science , biology , genetics
Strobilurins have become one of the most important classes of agricultural fungicides. To discover new strobilurin derivatives with high activity against resistant pathogens, a series of novel β ‐methoxyacrylate analogues were designed and synthesized by integrating substituted pyrimidine with a strobilurin pharmacophore. The compounds were confirmed and characterized by infrared, 1 H nuclear magnetic resonance, elemental analysis and mass spectroscopy. The bioassays indicated that most of the compounds 1 exhibited potent antifungal activity against Colletotrichum orbiculare , Botrytis cinerea Pers and Phytophthora capsici Leonian at the concentration of 50 μg/mL. Exhilaratingly, compound 1a (R=methyl) showed better antifungal activity against all the tested fungi than the commercial strobilurin fungicide azoxystrobin.