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An Efficient and Practical Synthesis of Dibenzo[d,f][1,3]‐dioxepines from 2,2′‐Dihydroxybiphenyl with Terminal Alkynes Catalyzed by Lewis Acid TiCl 4
Author(s) -
Wu Haisheng,
Yang Jin,
Wang Lei
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190225
Subject(s) - chemistry , catalysis , lewis acids and bases , terminal (telecommunication) , selectivity , medicinal chemistry , reaction conditions , combinatorial chemistry , organic chemistry , telecommunications , computer science
Abstract A synthetic strategy toward the cyclic addition of 2,2′‐dihydroxybiphenyl to terminal alkynes has been developed using Lewis acid TiCl 4 as catalyst. The reactions generated dibenzo[d,f][1,3]dioxepines derivatives in good yields with excellent regio‐selectivity in the presence of catalytic amount of TiCl 4 under mild reaction conditions.