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Synthesis of 1‐Aryl‐1 H ‐indazoles via a Ligand‐Free Copper‐ Catalyzed Intramolecular Amination Reaction
Author(s) -
Gao Mingshan,
Liu Xiujie,
Wang Xianyang,
Cai Qian,
Ding Ke
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190223
Subject(s) - chemistry , indazole , intramolecular force , amination , aryl , ligand (biochemistry) , catalysis , copper , intermolecular force , ullmann reaction , combinatorial chemistry , organic chemistry , medicinal chemistry , molecule , biochemistry , alkyl , receptor
A general synthesis of 1‐aryl‐1‐ H ‐indazoles from o ‐halogenated aryl aldehydes or ketones and aryl hydrazines was described. This protocol included an intermolecular condensation and a ligand‐free copper‐catalyzed intramolecular Ullmann‐type coupling reaction. This method was applied to a wide range of substrates to produce the indazole products in good yields.