Synthesis of 1‐Aryl‐1 H ‐indazoles via a Ligand‐Free Copper‐ Catalyzed Intramolecular Amination Reaction | Zendy

Gao Mingshan | Zendy; Liu Xiujie | Zendy; Wang Xianyang | Zendy; Cai Qian | Zendy; Ding Ke | Zendy

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Synthesis of 1‐Aryl‐1 H ‐indazoles via a Ligand‐Free Copper‐ Catalyzed Intramolecular Amination Reaction

Author(s) -

Gao Mingshan,

Liu Xiujie,

Wang Xianyang,

Cai Qian,

Ding Ke

Publication year - 2011

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201190223

Subject(s) - chemistry , indazole , intramolecular force , amination , aryl , ligand (biochemistry) , catalysis , copper , intermolecular force , ullmann reaction , combinatorial chemistry , organic chemistry , medicinal chemistry , molecule , biochemistry , alkyl , receptor

A general synthesis of 1‐aryl‐1‐ H ‐indazoles from o ‐halogenated aryl aldehydes or ketones and aryl hydrazines was described. This protocol included an intermolecular condensation and a ligand‐free copper‐catalyzed intramolecular Ullmann‐type coupling reaction. This method was applied to a wide range of substrates to produce the indazole products in good yields.

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