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A Mild and Highly Efficient Catalyst for Beckmann Rearrangement, BF 3 ·OEt 2
Author(s) -
An Na,
Pi Hongjun,
Liu Lifeng,
Du Wenting,
Deng Weiping
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190193
Subject(s) - chemistry , beckmann rearrangement , anhydrous , boron trifluoride , yield (engineering) , acetonitrile , catalysis , lewis acids and bases , stoichiometry , medicinal chemistry , fries rearrangement , organic chemistry , materials science , metallurgy
BF 3 ·OEt 2 (Boron trifluoride etherate), an inexpensive and commercially easily available Lewis acid stoichiometrically employed for Beckamann rearrangement in general, was now found to efficiently catalyze Beckmann rearrangement of ketoximes into their corresponding amides (up to 99% yield) in anhydrous acetonitrile under reflux temperature.