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A Fast and Highly Efficient Protocol for Reductive Amination of Aromatic Aldehydes Using NaBH 4 and Isoxazole Amines in an Ionic Liquid Medium
Author(s) -
Eligeti Rajanarendar,
Atthunuri Siva Rami Reddy,
Samala Raju,
Shaik Firoz Pasha,
Kundur Govardhan Reddy
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190155
Subject(s) - chemistry , ionic liquid , tetrafluoroborate , reductive amination , isoxazole , organic chemistry , amination , solvent , catalysis , combinatorial chemistry
Reductive amination of aromatic aldehydes using NaBH 4 and isoxazole amines is carried out in a Brønsted acidic ionic liquid 1‐methylimidazolium tetrafluoroborate [(HMIm)BF 4 ]. The ionic liquid plays dual roles of solvent as well as catalyst for the efficient transformation of aromatic aldehydes to heterocyclic substituted amines in excellent yields without any undesired side product formation. The newly synthesized compounds ( 3 , 6 and 7 ) were characterized by IR, 1 H NMR and mass spectral techniques.