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First Total Synthesis of (±)‐Puyanin and (±)‐4′‐ O ‐Methylbonannione
Author(s) -
Zhang Yuheng,
Yang Jinhui,
Li Hongjun,
Jiang Shizhi,
Li Yunfeng,
Liu Wanyi
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190116
Subject(s) - chemistry , regioselectivity , total synthesis , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
A facile approach for the first total synthesis of two naturally occurring geranylated flavonoids, (±)‐puyanin ( 1 ) and (±)‐4′‐ O ‐methylbonannione ( 2 ) has been obtained with total yields of 27% and 17.8%, respectively. The key steps were regioselective cyclization of geranylated trihydroxychalcone and regioselective geranylation of 2,4,6‐trihydroxyacetophenone.