Premium
An Efficient Synthesis of 3‐Alkyl‐2‐alkyliminooxazolidin‐4‐one via a Domino Reaction
Author(s) -
Liu Yongwei,
Li Zhengning,
Jiang Lan,
Zheng Aijun
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190082
Subject(s) - chemistry , carbodiimide , domino , alkyl , nucleophilic substitution , nucleophile , nucleophilic addition , intermolecular force , organic chemistry , cascade reaction , catalysis , medicinal chemistry , combinatorial chemistry , molecule
Abstract 3‐Alkyl‐2‐alkyliminooxazolidin‐4‐ones were prepared from a copper‐catalyzed domino intermolecular nucleophilic addition of α ‐hydroxy‐(or mecapto) carboxylic acid ester to carbodiimide and a followed nucleophilic substitution of the formed amino group to carboxylic acid ester. The reactions could be performed under convenient conditions and good yields were achieved in most cases.