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Asymmetric Direct Aldol Reaction of Cyclohexanone Catalyzed by ( N′ ‐Benzyl‐ N′ ‐ D ‐prolyl)‐ trans ‐4‐hydroxy‐ L ‐proline Hydrazide
Author(s) -
Cheng Chuanling,
Wang Wenliang
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190051
Subject(s) - chemistry , cyclohexanone , aldol reaction , proline , hydrazide , catalysis , organic chemistry , medicinal chemistry , amino acid , biochemistry
A new proline catalyst, namely ( N′ ‐benzyl‐ N′ ‐ D ‐prolyl)‐ trans ‐4‐hydroxy‐ L ‐proline hydrazide, has been prepared and proved to be a superior catalyst for the asymmetric aldol reaction of cyclohexanone and aromatic aldehydes, affording up to 98:2 dr and 98% ee .