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LiBr as an Efficient Catalyst for One‐pot Synthesis of Hantzsch 1,4‐Dihydropyridines under Mild Conditions
Author(s) -
Yadav D. K.,
Patel R.,
Srivastava V. P.,
Watal G.,
Yadav L. D. S.
Publication year - 2011
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190036
Subject(s) - chemistry , ammonium acetate , aldehyde , lithium bromide , acetonitrile , catalysis , ammonium bromide , condensation , organic chemistry , one pot synthesis , lithium (medication) , multi component reaction , condensation reaction , reaction conditions , combinatorial chemistry , high performance liquid chromatography , medicine , pulmonary surfactant , biochemistry , physics , heat exchanger , thermodynamics , endocrinology
A simple, inexpensive and efficient one‐pot synthesis of 1,4‐dihydropyridines has been accomplished via lithium bromide‐catalyzed Hantzsch three‐component condensation reaction of an aldehyde, α , β ‐ketoester and ammonium acetate in acetonitrile at room temperature in good to excellent yields. The present protocol is applicable to wide range of substrates including aliphatic, aromatic and heterocyclic aldehydes affording 1,4‐dihydropyridines.