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Efficient Preparation of the Key Intermediate in Corey's Tamiflu Synthesis
Author(s) -
Hong Zhangyong,
Cui Qi,
Peng Jiannan,
Hu Huan,
Chen Zeming
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190025
Subject(s) - chemistry , key (lock) , combinatorial chemistry , catalysis , scale (ratio) , organic chemistry , ecology , biology , physics , quantum mechanics
A very efficient two‐step synthesis was developed to prepare the key intermediate in Corey's Tamiflu synthesis. DBU (1,8‐diazabicyclo[5.4.0] undec‐7‐ene) was used as a multifunctional catalyst for a series of reactions in a one pot procedure. The new synthesis was featured by the good availability of the starting material and the ease of the synthetic steps. This method might be practical for large scale preparations.