Premium
Highly Efficient Palladacycle/Dihydroimidazolium Chloride System for the Suzuki‐Miyaura Cross‐Coupling of Aryl Halides (I, Br, Cl) with Arylboronic Acids
Author(s) -
Wang Haiming,
Wang Jinping,
Qiu Wenwei,
Yang Fan,
Liu Xiaofeng,
Tang Jie
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201190014
Subject(s) - chemistry , aryl , halide , carbene , chloride , ligand (biochemistry) , catalysis , medicinal chemistry , palladium , substrate (aquarium) , amine gas treating , coupling reaction , organic chemistry , aryl halide , combinatorial chemistry , polymer chemistry , receptor , oceanography , biochemistry , alkyl , geology
A combination of a tertiary amine‐based palladacycle and an N ‐heterocyclic carbene ligand precursor ( 1 , N , N ‐bis‐mesityl‐4,5‐dihydroimidazolium chloride) has been applied to catalyze the Suzuki‐Miyaura cross‐coupling of aryl halides with arylboronic acids. The substrate scope is general: a variety of electron rich and deficient aryl halides (I, Br, Cl) and arylboronic acids were found to undergo the cross‐coupling reaction in good to excellent yields at low catalyst loading of 0.01–1 mol%.